Recombinant Human MMP11, His-tagged
Cat.No. : | MMP11-33H |
Product Overview : | A DNA sequence encoding human matrix metallopeptidase 11 corresponding to amino acid (1-488) was expressed with a C-terminal polyhistidine tag |
- Specification
- Gene Information
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Description : | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP"s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP"s, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | PBS pH7.4 |
Molecular Mass : | The mature form of human matrix metallopeptidase 11 consists of 391 amino acids and has a predicted molecular mass of 44.1kDa. |
AA Sequence : | MAPAAWLRSAAARALLPPMLLLLLQ PPPLLARALPPDAHHLHAERRGPQP WHAALPSSPAPAPATQEAPRPASSL RPPRCGVPDPSDGLSARNRQKRFVL SGGRWEKTDLTYRILRFPWQLVQEQ VRQTMAEALKVWSDVTPLTFTEVHE GRADIMIDFARYWHGDDLPFDGPGG ILAHAFSPKTHREGDVHFDYDETWT IGDDQGTDLLQVAAHEFGHVLGLQH TTAAKALMSAFYTFRYPLSLSPDDC RGVQHLYGQPWPTVTSRTPALGPQA GIDTNEIAPLEPDAPPDACEASFDA VSTIRGELFFFKAGFVWRLRGGQLQ PGYPALASRHWQGLPSPVDAAFEDA QGHIWFFQGAQYWVYDGEKPVLGPA PLTELGLVRFPVHAALVWGPEKNKI YFFRGRDYWRFHPSTRRVDSPVPRR ATDWRGVPSEIDAAFQDADGYAYFL RGRLYWKFDPVKVKALEGFPRLVGP DFFGCAEPANTFL |
Purity : | >95% as determined by SDS-PAGE |
Storage : | Store it at +4°C for short term. For long term storage, store it at -20°C - -70°C. Avoid freeze-thaw cycles. |
Gene Name : | MMP11 matrix metallopeptidase 11 (stromelysin 3) [ Homo sapiens ] |
Official Symbol : | MMP11 |
Synonyms : | MMP11; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3) , STMY3; stromelysin-3; MMP-11; stromelysin III; ST3; SL-3; STMY3; |
Gene ID : | 4320 |
mRNA Refseq : | NM_005940 |
Protein Refseq : | NP_005931 |
MIM : | 185261 |
UniProt ID : | P24347 |
Chromosome Location : | 22q11.23 |
Pathway : | Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; |
Function : | calcium ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
MMP11-5417H | Recombinant Human MMP11 Protein, GST-tagged | +Inquiry |
MMP11-3367R | Recombinant Rat MMP11 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP11-5245H | Recombinant Human MMP11 Protein, GST/His-tagged | +Inquiry |
MMP11-5596M | Recombinant Mouse MMP11 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP11-258M | Recombinant Mouse MMP11 Protein, his-tagged, Phe102-Arg492 | +Inquiry |
◆ Native Protein | ||
MMP11-27648TH | Native Human MMP11 | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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