"CUL2" Related Products

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Recombinant Human CUL2/RBX1 protein

Cat.No.: CUL2-133H
Product Overview: Recombinant Human CUL2/RBX1 was coexpressed in Insect cells.
Source: Insect cells
Species: Human
Form: 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
Bio-activity: E3 Ligase Assay: The activity of Cul2/Rbx1 was validated indirectly through its ability to act as a substrate for Neddylation in the presence of the NEDD8 E3 ligase His-DCNL2 and thioester-loaded His-UBE2M-NEDD8. Incubation of Cul2/Rbx1 and thioester loaded His-UBE2M-NEDD8 in the presence or absence of His-DCNL2 at 4˚C was compared at two time points T0 and T2 minutes. Neddylation of the Cul2 subunit in the presence of His-DCNL2 was demonstrated.
Molecular Mass: Cul2=~87.1kDa; Rbx1=~12.3kDa
Purity: >75% by InstantBlue™ SDS-PAGE
Stability: 12 months at -70 centigrade; aliquot as required
Storage: Store product at –70 centigrade
Concentration: 0.5mg/ml
Gene Name: CUL2 cullin 2 [ Homo sapiens ]
Official Symbol: CUL2
Synonyms: CUL2; cullin 2; cullin-2; CUL-2; MGC131970;
Gene ID: 8453
mRNA Refseq: NM_001198777
Protein Refseq: NP_001185706
MIM: 603135
UniProt ID: Q13617
Chromosome Location: 10p11.2
Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; ECV complex, organism-specific biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem;
Function: protein binding; ubiquitin protein ligase binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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