Recombinant Human ZNRF1, GST-tagged

• Cat.No.: ZNRF1-134H
• Product Overview: Recombinant human ZNRF1 (amino acid residues 1-227), with N-terminal GST, was expressed in E.coli.

Specification

• Description: The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome-dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes (E1s), conjugating enzymes (E2s) and protein ligases (E3s). Zinc and Ring Finger protein 1 (ZNRF1) is a member of the Really Interesting New Gene (RING) E3 protein ligase family and cloning of the human gene was first described by Araki et al. (2001). ZNRF1 has been shown to be expressed in both the central and peripheral nervous system of rats during development and in adulthood (Araki et al., 2001).
• Source: E. coli
• Species: Human
• Tag: GST
• Form: 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
• Molecular Mass: ~50kDa
• Storage: 12 months at -70°C. Avoid multiple freeze/thaw cycles.
• Concentration: 0.5mg/ml

Gene Information

• Gene Name: ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase [ Homo sapiens ]
• Official Symbol: ZNRF1
• Synonyms: ZNRF1; zinc and ring finger 1, E3 ubiquitin protein ligase; zinc and ring finger 1; E3 ubiquitin-protein ligase ZNRF1; DKFZp434E229; FLJ14846; nin283; nerve injury gene 283; zinc/RING finger protein 1; zinc and ring finger protein 1; nerve injury-induced gene 283 protein; NIN283; FLJ46491; MGC15430
• Gene ID: 84937
• mRNA Refseq: NM_032268
• Protein Refseq: NP_115644
• MIM: 612060
• UniProt ID: Q8ND25
• Chromosome Location: 16q22.3
• Function: ligase activity; metal ion binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding