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Recombinant Human Methionine Adenosyltransferase II, Alpha, His-tagged

Cat. No.: MAT2A-113H
Product Overview: Recombinant MAT2A, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography techniques, 45.8 kDa (415 aa).
Description: Methionine adenosyltransferase II (MAT II) is a key enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver, MAT2A expression associates with growth, dedifferentiation, and cancer.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MNGQLNGFHE AFIEEGTFLF TSESVGEGHP DKICDQISDA VLDAHLQQDP DAKVACETVA KTGMILLAGE ITSRAAVDYQ KVVREAVKHI GYDDSSKGFD YKTCNVLVAL EQQSPDIAQG VHLDRNEEDI GAGDQGLMFG YATDETEECM PLTIVLAHKL NAKLAELRRN GTLPWLRPDS KTQVTVQYMQ DRGAVLPIRV HTIVISVQHD EEVCLDEMRD ALKEKVIKAV VPAKYLDEDT IYHLQPSGRF VIGGPQGDAG LTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKGGL CRRVLVQVSY AIGVSHPLSI SIFHYGTSQK SERELLEIVK KNFDLRPGVI VRDLDLKKPI YQRTAAYGHF GRDSFPWEVP KKLKY
Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Purity: > 95% by SDS - PAGE
Concentration: 1 mg/ml (determined by Bradford assay)
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: MAT2A methionine adenosyltransferase II, alpha [ Homo sapiens ]
Synonyms: MAT2A; methionine adenosyltransferase II, alpha; MATA2; MATII; SAMS2;EC2.5.1.6; SAMS2; MAT-II; S-adenosylmethionine synthetase isoform type-2; AMS2; MAT 2; Methionine adenosyltransferase 2; Methionine adenosyltransferase II
Gene ID: 4144
mRNA Refseq: NM_005911
Protein Refseq: NP_005902
MIM: 601468
UniProt ID: P31153
Chromosome Location: 2p11.2
Pathway: Biological oxidations; Metabolism of amino acids; Metabolism of polyamines
Function: ATP binding; cobalt ion binding; magnesium ion binding; ; methionine adenosyltransferase activity; nucleotide binding; potassium ion binding; protein binding; transferase activity

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