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Recombinant Human ANO4

Cat.No. : ANO4-970H
Product Overview : Recombinant Human ANO4 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Human
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : ANO4 anoctamin 4 [ Homo sapiens ]
Official Symbol : ANO4
Gene ID : 121601
mRNA Refseq : NM_178826.3
Protein Refseq : NP_849148.2
MIM : 610111
UniProt ID : Q32M45

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (22)

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Is ANO4 protein implicated in cancer? 01/09/2023

There is limited evidence suggesting a possible association between ANO4 protein and cancer. Studies have shown altered ANO4 expression in certain cancer types, but more research is necessary to determine its precise role in tumorigenesis.

Are there any known inhibitors or activators of ANO4 protein? 05/07/2022

Currently, there are no specific inhibitors or activators of ANO4 protein that have been widely characterized. However, ongoing research is focusing on identifying small molecules or compounds that can modulate its activity.

Can changes in ANO4 protein expression or function contribute to disease development? 04/28/2022

It is still not fully understood whether alterations in ANO4 protein expression or function directly contribute to disease development. However, a better understanding of its role in various tissues may provide insights into potential disease mechanisms and therapeutic strategies.

Does ANO4 protein play a role in pain processing? 02/27/2022

Recent studies have indicated that ANO4 protein may be involved in pain processing. It has been found to modulate nociceptor excitability and contribute to inflammatory pain hypersensitivity.

Are there any inhibitors or activators of ANO4 protein? 01/18/2022

Currently, there are no specific inhibitors or activators of ANO4 protein. However, ongoing research may identify substances or compounds that can modulate its activity.

Are there any genetic disorders associated with ANO4 protein? 11/13/2021

Yes, genetic disorders associated with ANO4 protein have been identified. For example, mutations in ANO4 have been linked to autosomal recessive spinocerebellar ataxia.

Does ANO4 protein interact with other proteins? 05/19/2021

Yes, ANO4 protein can interact with various proteins to form functional complexes. For example, it has been found to interact with the cystic fibrosis transmembrane conductance regulator (CFTR), another chloride channel, in airway epithelial cells.

Can ANO4 mutations be inherited? 08/21/2020

Yes, ANO4 mutations can be inherited. In the case of gnathodiaphyseal dysplasia, it is inherited in an autosomal dominant manner, which means a single copy of the mutated gene from one parent is sufficient to cause the condition.

Are there any diseases or conditions associated with ANO4 protein mutations? 06/16/2020

Mutations in the ANO4 gene have been identified in individuals with hereditary gnathodiaphyseal dysplasia, which is a rare skeletal disorder characterized by bone abnormalities in the jaw and other skeletal structures.

Are there any animal models available for studying ANO4 protein function? 05/25/2020

Yes, animal models, such as mice with ANO4 gene knockout or overexpression, have been generated to investigate the physiological roles of ANO4 protein. These models can provide valuable insights into its functions and associated diseases.

Are there any drugs targeting ANO4 protein currently in development? 03/21/2020

As of now, there are no specific drugs targeting ANO4 protein in clinical use or advanced stages of development. However, with increasing knowledge about its structure and function, it is possible that novel therapeutic interventions may be explored in the future.

Is ANO4 protein involved in any other physiological processes? 12/19/2019

While the exact physiological roles of ANO4 protein are still being investigated, recent studies suggest its involvement in processes such as insulin secretion in pancreatic beta cells and regulation of smooth muscle contraction.

Are there any known genetic mutations or polymorphisms in the ANO4 gene? 11/26/2019

Yes, genetic mutations in the ANO4 gene have been identified in individuals with gnathodiaphyseal dysplasia. However, the full spectrum of mutations and their effects on protein function and disease development is not yet fully characterized.

How is ANO4 protein expression regulated in different tissues? 10/12/2019

The regulation of ANO4 protein expression in different tissues is not well understood. Further research is needed to determine the factors and mechanisms that control its expression levels.

Is ANO4 protein involved in sensory perception? 09/25/2019

ANO4 protein has been implicated in sensory perception, particularly in taste perception. It is expressed in taste bud cells and appears to play a role in the detection of sour taste stimuli.

Are there any disease-associated mutations identified in the ANO4 gene? 08/06/2019

Yes, several disease-associated mutations have been identified in the ANO4 gene. For example, mutations in ANO4 have been linked to hereditary motor and sensory neuropathy and gnathodiaphyseal dysplasia.

Can ANO4 protein be used as a biomarker for any diseases? 04/28/2018

The potential use of ANO4 protein as a biomarker for specific diseases is still being explored. However, some studies have suggested its potential as a biomarker for certain cancers, such as lung and pancreatic cancer.

Can changes in ANO4 protein expression or function affect neuronal activity? 12/15/2017

There is evidence to suggest that changes in ANO4 protein expression or function can affect neuronal activity. ANO4 has been shown to regulate neuronal excitability and synaptic transmission in both the central and peripheral nervous systems.

Does ANO4 protein have any structural similarities with other proteins? 08/27/2017

ANO4 protein belongs to the Anoctamin family, which comprises ten closely related proteins. It shares structural similarities with other members of the family, including conserved transmembrane domains and intracellular loops.

What are the evolutionary origins of ANO4 protein? 11/11/2016

ANO4 protein is evolutionarily conserved and found in various vertebrate species. Its presence indicates that it likely has important functions across different organisms.

Is ANO4 protein localized to specific subcellular compartments? 03/08/2016

ANO4 protein is primarily localized to the plasma membrane, where it functions as a chloride channel. However, it may also have other subcellular localizations depending on the context and cell type. Further research is needed to determine its precise localization in different cellular compartments.

Can ANO4 protein be regulated by signaling pathways? 01/21/2016

Yes, ANO4 protein can be regulated by various signaling pathways. For example, activation of protein kinase A (PKA) has been shown to enhance ANO4 channel activity.

Customer Reviews (4)

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Reviews
04/14/2021

    ANO4 protein demonstrates great utility in protein electron microscopy structure analysis.

    08/30/2019

      The high-quality ANO4 protein available from reliable manufacturers ensures accurate detection and quantification of ANO4 protein levels in samples, providing valuable insights into its biological roles and signaling pathways.

      12/18/2018

        The use of ANO4 protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.

        11/07/2016

          In WB experiments, ANO4 protein exhibits exceptional performance, making it an ideal tool for studying ANO4 protein expression, regulation, and potential functional changes.

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