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Recombinant Human SYN1, MYC/DDK-tagged

Cat.No. : SYN1-16H
Product Overview : Recombinant Human SYN1, transcript variant Ia, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
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Description : This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Source : HEK293 cells
Species : Human
Tag : MYC/DDK
Molecular Mass : 73.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : SYN1 synapsin I [ Homo sapiens (human) ]
Official Symbol : SYN1
Synonyms : SYN1; synapsin I; SYNI; SYN1a; SYN1b; synapsin-1; brain protein 4.1
Gene ID : 6853
mRNA Refseq : NM_006950
Protein Refseq : NP_008881
MIM : 313440
UniProt ID : P17600
Chromosome Location : Xp11.23
Pathway : BDNF signaling pathway; Monoamine Transport; Neurotransmitter Release Cycle
Function : ATP binding; calcium-dependent protein binding; catalytic activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does SYN1 protein contribute to epilepsy? 03/05/2020

Altered expression or function of SYN1 has been linked to epilepsy, suggesting its potential role as a therapeutic target for managing seizure disorders.

Can SYN1 be a potential therapeutic target for schizophrenia? 05/21/2019

There is emerging research suggesting that SYN1 dysfunction may be associated with schizophrenia, making it a potential target for therapeutic interventions.

Can SYN1 be a target for drug development? 09/29/2018

Yes, SYN1 is considered a potential target for drug development in the context of neurological disorders to modulate neurotransmission and mitigate associated symptoms.

How is SYN1 involved in synaptic plasticity? 06/24/2017

SYN1 plays a role in synaptic plasticity by influencing the dynamic regulation of synaptic vesicles, which is crucial for learning and memory processes.

Is there a connection between SYN1 and Alzheimer's disease? 06/01/2017

Some studies suggest that alterations in SYN1 expression may contribute to synaptic dysfunction in Alzheimer's disease, making it a subject of interest for further research.

Customer Reviews (3)

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Reviews
01/16/2018

    Its purity and reliability ensure reliable and reproducible results in a variety of research applications.

    03/20/2017

      The SYN1 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).

      08/31/2016

        The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.

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