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Active Recombinant Human ARSB, His-tagged

Cat.No. : ARSB-1062H
Product Overview : Recombinant Human ARSB(Ser37-Met533), fused with a C-terminal 10-His tag, was expressed in CHO Cells.
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Description : Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Source : CHO Cells
Species : Human
Tag : His
Predicted N Terminal : Ser37
Form : Supplied as a 0.2 µm filtered solution in Tris and NaCl.
Bio-activity : Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS). The specific activity is >3,000 pmol/min/µg.
Molecular Mass : Predicted Molecular Mass: 57 kDaSDS-PAGE: 80 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 ºC as supplied.3 months, -20 to -70 ºC under sterile conditions after opening.
Gene Name : ARSB arylsulfatase B [ Homo sapiens (human) ]
Official Symbol : ARSB
Synonyms : ARSB; arylsulfatase B; ASB; G4S; MPS6; N-acetylgalactosamine-4-sulfatase; NP_000037.2; EC 3.1.6.12; NP_942002.1
Gene ID : 411
mRNA Refseq : NM_000046
Protein Refseq : NP_000037
MIM : 611542
UniProt ID : P15848
Chromosome Location : 5q14.1
Pathway : CS/DS degradation; Chondroitin sulfate degradation; Chondroitin sulfate/dermatan sulfate metabolism
Function : N-acetylgalactosamine-4-sulfatase activity; arylsulfatase activity; metal ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is the ARSB protein involved in any other biological processes or diseases? 12/22/2021

Although the primary function of the ARSB protein is related to the breakdown of GAGs, recent studies have suggested its involvement in other biological processes. It has been implicated in cellular signaling, inflammatory responses, and tissue remodeling. Additionally, ARSB mutations or dysregulation have been associated with certain cancers, neurodegenerative disorders, and metabolic disorders.

Are there any known mutations or variations in the ARSB gene? 01/22/2021

Yes, mutations in the ARSB gene can cause mucopolysaccharidosis type VI (MPS VI). Over 170 different mutations have been identified, including insertions, deletions, and point mutations, each leading to a deficiency in ARSB enzyme activity.

What are the consequences of ARSB protein deficiency? 10/14/2020

A deficiency in the ARSB protein leads to a rare inherited disorder called mucopolysaccharidosis type VI (MPS VI). This condition results in the accumulation of GAGs in various tissues and organs, causing various symptoms including skeletal abnormalities, cardiovascular issues, respiratory problems, and impaired vision and hearing.

How is the ARSB protein regulated in the body? 06/06/2020

The expression of the ARSB protein is regulated by various factors, including transcription factors and signaling pathways that control gene expression. Additionally, post-translational modifications such as phosphorylation or glycosylation can affect its activity and localization within the cell.

Are there any treatments available for mucopolysaccharidosis type VI? 02/24/2018

Yes, there are treatments available for mucopolysaccharidosis type VI. Enzyme replacement therapy (ERT) involves regular infusion of a man-made version of the ARSB enzyme to help break down the accumulated GAGs. Additionally, supportive therapies such as physical therapy, surgery, and medications are utilized to manage symptoms and complications. Gene therapy approaches are also being explored.

How is the ARSB protein related to lysosomal storage disorders? 09/01/2017

Mutations in the ARSB gene lead to a deficiency in the ARSB enzyme, resulting in the accumulation of GAGs within lysosomes. This accumulation is characteristic of lysosomal storage disorders, including mucopolysaccharidosis type VI. These disorders occur due to impaired lysosomal function, which leads to the build-up of undigested substances and subsequent cellular dysfunction.

Customer Reviews (3)

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Reviews
01/25/2023

    the ARSB protein has proven to be a valuable asset in protein electron microscopy structure analysis.

    09/09/2019

      By utilizing the ARSB protein, researchers can unravel the intricate three-dimensional architecture of proteins, furthering our understanding of their function and facilitating the development of novel therapeutic interventions.

      08/03/2019

        The ARSB protein's superior performance in ELISA paves the way for robust and precise data analysis, providing invaluable insights into various biological processes.

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