Native Bordetella pertussis Perrtussis toxin


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Native Bordetella pertussis Perrtussis toxin

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Cat.No. : PT-141B
Product Overview : This product was highly purified (>90% pure) from Bordetella pertussis strain Tohama. Cytotoxicity of the PT was confirmed by morphological alteration of CHO cells after treatment with 0.1 ng/ml of PT.
Description : Perrtussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordeterra pertussis. PT catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt and prevents intracellular signal transduction involving the G proteins. PT consists of one moplecule of each S1 (26 kDa), S2 (22 kDa), S3 (22 kDa), S5 (12 kDa) and two molecule of S4 (12 kDa).
Source : Bordetella pertussis
Species : Bordetella pertussis
Form : 83 μg/ml in 10% glycerol 10 mM phoshate buffer (pH 7.4), 137 mM NaCl
Applications : 1. Studies on the signal transduction of the trimeric GTP binding proteins. 2. Therapeutic role in treating a number of diseases including hypertention, viral and autoimumune inhibitions.
Storage : Store at -70℃

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