"dnt" Related Products

Native Bordetella bronchiseptica Dermonecrotic Toxin

Cat.No.: dnt-142B
Product Overview: DNT was purified from B. bronchiseptica strain S798 by propriety chromatography and differential precipitation method.
Description: Dermonecrotic toxin (DNT) is a common toxin produced by pathogenic bacteria belonging to the genus Bordetella, such as B. pertussis, B. parapertussis, and B. bronchiseptica. This toxin activates small GTP-binding proteins such as Rho, Rac and Cdc42 through deamidation or polyamination for downstream signaling pathways.
Source: B. bronchiseptica
Species: B. bronchiseptica
Form: 0.53 mg/ml of DNT in 50 mM sodium phosphate buffer (pH 7.2), 1 M urea, 0.3 M sodium sulfate, filter-sterilized.
Bio-activity: DNT at 5 ng/ml induces ballooning morphological change in cultured mouse osteoblastic cell line MC3T3-E1.
Purity: More than 95 % purity by SDS-PAGE (CBB staining)
Applications: 1) For the studies of the signaling pathways mediated by small GTP-binding proteins. 2) Antigen to be used for detection of infection of Bordetella by immunological method.
Storage: Store at 4℃

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