|Product Overview:||Recombinant NS0-derived human alpha-L-Iduronidase/IDUA protein (Ala26-Pro653 (Ala26Thr)), with a C-terminal 10-His tag, was expressed in mouse myeloma cell line.|
|Description:||This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I).|
|Molecular Mass:||71 kDa|
|N-terminal Sequence Analysis:||Thr26|
|Endotoxin:||<1.0 EU per 1 μg of the protein by the LAL method.|
|Purity:||>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.|
|Storage:||Avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
3 months, -20 to -70 centigrade under sterile conditions after opening.
|Storage Buffer:||Supplied as a 0.2 μm filtered solution in Sodium Acetate, NaCl and Glycerol.|
|Gene Name:||IDUA iduronidase alpha-L- [ Homo sapiens (human) ]|
|Synonyms:||IDUA; iduronidase alpha-L-; IDA; MPS1; MPSI; alpha-L-iduronidase; mucopolysaccharidosis type I; EC 184.108.40.206|