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Recombinant Human IDUA Protein, His-tagged

Cat.No.: IDUA-196H
Product Overview: Recombinant NS0-derived human alpha-L-Iduronidase/IDUA protein (Ala26-Pro653 (Ala26Thr)), with a C-terminal 10-His tag, was expressed in mouse myeloma cell line.
Description: This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I).
Source: NS0
Species: Human
Tag : His
Molecular Mass: 71 kDa
N-terminal Sequence Analysis: Thr26
Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage: Avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
3 months, -20 to -70 centigrade under sterile conditions after opening.
Storage Buffer: Supplied as a 0.2 μm filtered solution in Sodium Acetate, NaCl and Glycerol.
Gene Name: IDUA iduronidase alpha-L- [ Homo sapiens (human) ]
Official Symbol: IDUA
Synonyms: IDUA; iduronidase alpha-L-; IDA; MPS1; MPSI; alpha-L-iduronidase; mucopolysaccharidosis type I; EC 3.2.1.76
Gene ID: 3425
mRNA Refseq: NM_000203
Protein Refseq: NP_000194
MIM: 252800
UniProt ID: P35475

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