Recombinant Human IL31 protein IL31-641H

Recombinant Human IL31 protein

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Recombinant Human IL31 protein

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Cat.No. : IL31-641H
Product Overview : Recombinant Human IL31 protein was expressed in Escherichia coli.
Description : Human IL-31 gene is located on Chr.12. It expresses the IL-31 protein at low levels in the type 2 helper T cells, which exits in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. This protein shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. IL-31 signals through IL-31 receptor A and oncostatin M receptor subunits and can activate STAT3 through receptors and maybe involve in skin immunity. It regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Human IL-31 shares 24 % a.a. sequence identity in the mature protein with mouse IL-31.
Source : E.coli
Species : Human
Form : Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.
Bio-activity : Fully biologically active when compared to standard. The specific activity is determined by inducing STAT3 activation using human U-87 MG cells. 5 ng/mL of rHuIL-31 can effectively induce STAT3 activation.
Molecular Mass : Approximately 15.8 kDa, a single non-glycosylated polypeptide chain containing 141 amino acids.
Protein length : 141
AA Sequence : SHTLPVRLLRPSDDV QKIVEELQSLSKMLL KDVEEEKGVLVSQNY TLPCLSPDAQPPNNI HSPAIRAYLKTIRQL DNKSVIDEIIEHLDK LIFQDAPETNISVPT DTHECKRFILTISQQ FSECMDLALKSLTSG AQQATT
Endotoxin : Less than 1 EU/µg of rHuIL-31 as determined by LAL method.
Purity : >97% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
SDS-PAGE of IL31-641H :

Gene Name : IL31
Official Symbol : IL31
Synonyms : IL31; interleukin 31; interleukin-31; IL 31; IL-31;
Gene ID : 386653
mRNA Refseq : NM_001014336
Protein Refseq : NP_001014358
MIM : 609509
UniProt ID : Q6EBC2

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