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Active Recombinant Human CASP8, His-tagged

Cat.No. : CASP8-26H
Product Overview : Recombinant Human CASP8 (a.a: 200 – 496) fussed with His tag at C-terminal was expressed in E. coli.
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Description : Caspase-8 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Caspase-8 has been associated with chronic inflammation and neurodegenerative disorders including Alzheimer’s, Huntington’s, and Parkinson’s. Procaspase-8 is autocleaved between the prodomain and large protease subunit (p18). The cleavage product, p30, contains both the large (p18) and small (p10 [His-tag]) protease subunits. p30 is further processed to the p18 and p10 subunits, which dimerize to form active enzyme.
Source : E. coli
Species : Human
Tag : His
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, 3 mM DTT and 20% glycerol.
Bio-activity : ≥ 1145 pmol/min/µg
Molecular Mass : 34.5 kDa
Applications : Useful for the study of enzyme kinetics, screening inhibitors,and selectivity profiling.
Stability : >6 months at -80 centigrade.
Warning : Avoid freeze/thaw cycles.
Gene Name : CASP8 caspase 8, apoptosis-related cysteine peptidase [ Homo sapiens ]
Official Symbol : CASP8
Synonyms : CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; ICE-like apoptotic protease 5; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MORT1-associated ced-3 homolog; apoptotic cysteine protease; apoptotic protease Mch-5; caspase 8, apoptosis-related cysteine protease
Gene ID : 841
mRNA Refseq : NM_001228
Protein Refseq : NP_001219
MIM : 601763
UniProt ID : Q14790
Chromosome Location : 2q33-q34
Pathway : AGE/RAGE pathway, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Alzheimer's disease, conserved biosystem
Function : cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; death effector domain binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to study the regulatory mechanism of CASP8 protein? 11/28/2022

Studying the regulatory mechanism of CASP8 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, protein interaction, etc.

What are the mutation types of CASP8 protein? 08/06/2022

The mutation types of CASP8 protein include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

What is the relationship between CASP8 protein and other genes or proteins? 06/07/2022

CASP8 protein has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

What is the specific role of CASP8 protein in apoptosis? 06/05/2021

CASP8 protein plays a key role in apoptosis, and its activation can activate downstream effector molecules to trigger programmed cell death.

How to detect and analyze mutations in CASP8 protein? 02/22/2021

Mutations in the CASP8 protein can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to treat diseases by regulating the level of CASP8 protein? 12/11/2019

By regulating the level of CASP8 protein, some diseases related to apoptosis can be treated, such as by inhibiting its activity or regulating its expression.

Customer Reviews (3)

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Reviews
04/01/2022

    CASP8 is highly stable.

    03/21/2022

      The reduction of the synthesis cost of this protein leads to the increase of the application.

      04/02/2021

        CASP8 has a high specificity.

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