Active Recombinant Human CASP8, His-tagged
Cat.No. : | CASP8-26H |
Product Overview : | Recombinant Human CASP8 (a.a: 200 – 496) fussed with His tag at C-terminal was expressed in E. coli. |
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- Gene Information
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Description : | Caspase-8 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Caspase-8 has been associated with chronic inflammation and neurodegenerative disorders including Alzheimer’s, Huntington’s, and Parkinson’s. Procaspase-8 is autocleaved between the prodomain and large protease subunit (p18). The cleavage product, p30, contains both the large (p18) and small (p10 [His-tag]) protease subunits. p30 is further processed to the p18 and p10 subunits, which dimerize to form active enzyme. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, 3 mM DTT and 20% glycerol. |
Bio-activity : | ≥ 1145 pmol/min/µg |
Molecular Mass : | 34.5 kDa |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors,and selectivity profiling. |
Stability : | >6 months at -80 centigrade. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | CASP8 caspase 8, apoptosis-related cysteine peptidase [ Homo sapiens ] |
Official Symbol : | CASP8 |
Synonyms : | CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; ICE-like apoptotic protease 5; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MORT1-associated ced-3 homolog; apoptotic cysteine protease; apoptotic protease Mch-5; caspase 8, apoptosis-related cysteine protease |
Gene ID : | 841 |
mRNA Refseq : | NM_001228 |
Protein Refseq : | NP_001219 |
MIM : | 601763 |
UniProt ID : | Q14790 |
Chromosome Location : | 2q33-q34 |
Pathway : | AGE/RAGE pathway, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Alzheimer's disease, conserved biosystem |
Function : | cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; death effector domain binding |
Products Types
◆ Recombinant Protein | ||
CASP8-26606TH | Active Recombinant Human CASP8 Protein | +Inquiry |
CASP8-4937H | Recombinant Human CASP8 Protein(217–374aa), His-tagged | +Inquiry |
CASP8-804R | Recombinant Rat CASP8 Protein, His (Fc)-Avi-tagged | +Inquiry |
CASP8-1247M | Recombinant Mouse CASP8 Protein, His (Fc)-Avi-tagged | +Inquiry |
CASP8-7828H | Recombinant Human CASP8 protein, His & T7-tagged | +Inquiry |
◆ Lysates | ||
CASP8-7829HCL | Recombinant Human CASP8 293 Cell Lysate | +Inquiry |
CASP8-7831HCL | Recombinant Human CASP8 293 Cell Lysate | +Inquiry |
CASP8-7830HCL | Recombinant Human CASP8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudying the regulatory mechanism of CASP8 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, protein interaction, etc.
The mutation types of CASP8 protein include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
CASP8 protein has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.
CASP8 protein plays a key role in apoptosis, and its activation can activate downstream effector molecules to trigger programmed cell death.
Mutations in the CASP8 protein can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
By regulating the level of CASP8 protein, some diseases related to apoptosis can be treated, such as by inhibiting its activity or regulating its expression.
Customer Reviews (3)
Write a reviewCASP8 is highly stable.
The reduction of the synthesis cost of this protein leads to the increase of the application.
CASP8 has a high specificity.
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