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Recombinant Human ICOSLG, His-tagged, Biotinylated

Cat.No.: ICOSLG-539H
Product Overview: he recombinant human B7-H2/ICOSL/CD275 ECD is expressed as a 249 amino acid protein consisting of Asp19 - Thr256 region of B7-H2 (UniProt accession #O75144) and a C-terminal His-tag. It contains 6 potential sites for N-linked glycosylation.
Source: Human cells
Species: Human
Tag: His
Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity: Binds human ICOS and stimulates human T cell proliferation in the presence of anti-CD3.
Molecular Mass: Calculated molecular mass 27.8 kDa; estimated by SDS-PAGE under reducing condition 50-60 kDa probably due to glycosylation.
AA Sequence: DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLR GDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRP NVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDK ITENPVSTGEKNAATSTGHHHHHHHH
Endotoxin: <0.1 eu per 1 μg of purified recombinant protein determined by the
Purity: >95% judged by SDS-PAGE under reducing condition
Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name: ICOSLG inducible T-cell co-stimulator ligand [ Homo sapiens ]
Official Symbol: ICOSLG
Synonyms: ICOSLG; inducible T-cell co-stimulator ligand; ICOSL; ICOS ligand; B7 homolog 2; B7 homologue 2; B7 H2; B7 related protein 1; B7H2; B7RP 1; B7RP1; CD275; GL50; ICOS L; KIAA0653; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand; B7-H2; LICOS; B7RP-1; ICOS-L;
Gene ID: 23308
mRNA Refseq: NM_015259
Protein Refseq: NP_056074
MIM: 605717
UniProt ID: O75144
Chromosome Location: 21q22.3
Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem;
Function: receptor binding;

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