"SOX10" Related Products

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Recombinant Human SOX10 protein, MYC/DDK-tagged

Cat.No.: SOX10-1565H
Product Overview: Recombinant Human SOX10, fussed with MYC/DDK tag at C-terminal, was expressed in HEK293 cells.
Description: This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
Source: HEK293
Species: Human
Tag: MYC/DDK
Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass: 49.7 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: SOX10 SRY (sex determining region Y)-box 10 [ Homo sapiens ]
Official Symbol: SOX10
Synonyms: SOX10; SRY (sex determining region Y)-box 10; transcription factor SOX-10; DOM; dominant megacolon; mouse; human homolog of; WS2E; WS4; SRY-related HMG-box gene 10; dominant megacolon, mouse, human homolog of; PCWH; WS4C; MGC15649;
Gene ID: 6663
mRNA Refseq: NM_006941
Protein Refseq: NP_008872
MIM: 602229
UniProt ID: P56693
Chromosome Location: 22q13.1
Function: DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding; chromatin binding; identical protein binding; protein binding; transcription coactivator activity; transcription regulatory region DNA binding;

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