Recombinant Human SOX10 protein, MYC/DDK-tagged SOX10-1565H

Recombinant Human SOX10 protein, MYC/DDK-tagged


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Recombinant Human SOX10 protein, MYC/DDK-tagged

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Cat.No. : SOX10-1565H
Product Overview : Recombinant Human SOX10, fussed with MYC/DDK tag at C-terminal, was expressed in HEK293 cells.
Description : This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
Source : HEK293
Species : Human
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 49.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Notes : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : SOX10 SRY (sex determining region Y)-box 10 [ Homo sapiens ]
Official Symbol : SOX10
Synonyms : SOX10; SRY (sex determining region Y)-box 10; transcription factor SOX-10; DOM; dominant megacolon; mouse; human homolog of; WS2E; WS4; SRY-related HMG-box gene 10; dominant megacolon, mouse, human homolog of; PCWH; WS4C; MGC15649;
Gene ID : 6663
mRNA Refseq : NM_006941
Protein Refseq : NP_008872
MIM : 602229
UniProt ID : P56693
Chromosome Location : 22q13.1
Function : DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding; chromatin binding; identical protein binding; protein binding; transcription coactivator activity; transcription regulatory region DNA binding;

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