"RNASEH1" Related Products

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Recombinant Human RNASEH1 protein, His-tagged

Cat.No.: RNASEH1-4892H
Product Overview: Recombinant Human RNASEH1 fussed with His tag was expressed in E. coli.
Description: RNHA is an endonuclease which specifically degrades the RNA of RNA-DNA hybrids. Localized to the nucleus, the RNHA protein mediates the removal of Okazaki fragment RNA primers which are present on the lagging strand during DNA replication. RNHA catalyzes the endonucleolytic cleavage of RNA to a 5'-phosphomonoester and is capable of binding magnesium or manganese as cofactors.
Source: E. coli
Species: Human
Tag: His
Form: 0.05M Tris, 0.1M NaCl, 2mNDTT, pH8.7
Bio-activity: DNA-RNA hybrid cleavage: RNA 5’gacaccugauucugauuc; DNA 5’gaatcaggtgtc.Buffer: 50mM Tris-pH7.9, 50mMNaCl,5mM MgCl2, 1mM DTT, 20ug/ml BSA, 4%glycerol. Analysis by 12% TBE gel. Assays Pending.
Molecular Mass: approx.33kD
Purity: >95%
Applications: RNase H1 assays; Elisa/Western Blot; DNA/RNA hybrid Assay
Stability: At least 6 months at -75 centigrade
Storage: Store at -75 centigrade
Concentration: 0.1mg/ml
Gene Name: RNASEH1 ribonuclease H1 [ Homo sapiens ]
Official Symbol: RNASEH1
Synonyms: RNASEH1; ribonuclease H1; RNase H1; ribonuclease H type II; RNH1; H1RNA;
Gene ID: 246243
mRNA Refseq: NM_002936
Protein Refseq: NP_002927
MIM: 604123
UniProt ID: O60930
Chromosome Location: 2p25
Pathway: DNA replication, organism-specific biosystem; DNA replication, conserved biosystem;
Function: RNA binding; endonuclease activity; hydrolase activity; magnesium ion binding; nucleic acid binding; protein homodimerization activity; ribonuclease H activity; ribonuclease activity;

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