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Active Recombinant Human KDR, His-tagged, Biotinylated

Cat.No. : KDR-630H
Product Overview : The recombinant human KDR/VEGFR2/CD309 extracellular or ecto-domain (ECD) is expressed as a 756 amino acid protein consisting of Ala20 - Glu764 region of KDR and a C-terminal His-tag. It contains 18 potential N-linked glycosylation sites.
  • Specification
  • Gene Information
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Source : Human cells
Species : Human
Tag : His
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds VEGF and inhibits VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC).
Molecular Mass : Calculated molecular mass (kDa): 84.6; Estimated by SDS-PAGE under reducing condition (kDa): 110-120 suggesting that the protein is glycosylated.
AA Sequence : ASVGLPSVSLDLPRLSIQKDILTIK ANTTLQITCRGQRDLDWLWPNNQSG SEQRVEVTECSDGLFCKTLTIPKVI GNDTGAYKCFYRETDLASVIYVYVQ DYRSPFIASVSDQHGVVYITENKNK TVVIPCLGSISNLNVSLCARYPEK RFVPDGNRISWDSKKGFTIPSYMIS YAGMVFCEAKINDESYQSIMYIVVV VGYRIYDVVLSPSHGIELSVGEKL VLNCTARTELNVGIDFNWEYPSSKH QHKKLVNRDLKTQSGSEMKKFLSTL TIDGITRSDQGLYTCAASSGLMTK KNSTFVRVHEKPFVAFGSGMESLVE ATVGERVRIPAKYLGYPPPEIKWYK NGIPLESNHTIKAGHVLTIMEVSE RDTGNYTVILTNPISKEKQSHVVSL VVYVPPQIGEKSLISPVDSYQYGTT QTLTCTVYAIPPPHHIHWYWQLEEE CANEPSHAVSVTNPYPCEEWRSVED FQGGNKIEVNKNQFALIEGKNKTVS TLVIQAANVSALYKCEAVNKVGRG ERVISFHVTRGPEITLQPDMQPTEQ ESVSLWCTADRSTFENLTWYKLGPQ PLPIHVGELPTPVCKNLDTLWKLN ATMFSNSTNDILIMELKNASLQDQG DYVCLAQDRKTKKRHCVVRQLTVLE RVAPTITGNLENQTTSIGESIEVS CTASGNPPPQIMWFKDNETLVEDSG IVLKDGNRNLTIRRVRKEDEGLYTC QACSVLGCAKVEAFFIIEGAQEKT NLESTGHHHHHHHH
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >90% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ]
Official Symbol : KDR
Synonyms : KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2; CD309; FLK1; VEGFR; VEGFR2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor;
Gene ID : 3791
mRNA Refseq : NM_002253
Protein Refseq : NP_002244
MIM : 191306
UniProt ID : P35968
Chromosome Location : 4q11-q12
Pathway : Angiogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem;
Function : ATP binding; Hsp90 protein binding; growth factor binding; integrin binding; nucleotide binding; protein binding; protein tyrosine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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