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Recombinant Human Proliferating Cell Nuclear Antigen
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Cat. No. : | PCNA-536H |
Product Overview : | Recombinant human Proliferating Cell Nuclear Antigen, was expressed inE.coliand purified by conventional chromatography techniques. MW = 28 kDa (261 aa). |
Description : | PCNA (Proliferating Cell Nuclear Antigen) is found in the nucleus and is a cofactor of DNA polymerase delta. This protein is associated with DNA synthesis and repair. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. It appears during late G1- phase, S-phase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA may be induced by UV irradiation, growth factors and eventually by neighbouring tumours. |
Source : | Escherichia Coli. |
Form : | Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 2 mM EDTA 20% glycerol. |
Purity : | > 95% by SDS - PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Sequences Of Amino Acids : | MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLR SEG FDTY RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVF EAP NQE K VSDYEMKLMD LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLN FFTKATP LSSTVTLSMS ADVPLVVEYK IADMGHLKYY LAPKIEDEEG S. |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
The assembled human DNA clamp, a trimer of the protein PCNA. : |
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Gene Name : | PCNA proliferating cell nuclear antigen [ Homo sapiens ] |
Synonyms : | MGC8367; PCNA; Proliferating cell nuclear antigen; Cyclin; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein |
Gene ID : | 5111 |
mRNA Refseq : | NM_002592 |
Protein Refseq : | NP_002583 |
MIM : | 176740 |
UniProt ID : | P12004 |
Chromosome Location : | 20pter-p12 |
Pathway : | Base excision repair; Cell cycle; DNA replication; Mismatch repair; Nucleotide excision repair; Cell Cycle, Mitotic; DNA Repair; DNA Replication; Telomere Maintenance |
Function : | DNA binding; DNA polymerase processivity factor activity; MutLalpha complex binding; dinucleotide insertion or deletion binding; protein binding; purine-specific mismatch base pair DNA N-glycosylase activity |
◆ Recombinant Protein
Pcna-4715M | Recombinant Mouse Pcna Protein, Myc/DDK-tagged | +Inquiry |
PCNA-626H | Recombinant Human PCNA Protein, MYC/DDK-tagged | +Inquiry |
PCNA-8977Z | Recombinant Zebrafish PCNA | +Inquiry |
PCNA-4302R | Recombinant Rat PCNA Protein | +Inquiry |
PCNA-1534Y | Recombinant Yeast PCNA protein | +Inquiry |
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◆ Lysates
PCNA-500HCL | Recombinant Human PCNA cell lysate | +Inquiry |
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