Recombinant Human Fms-Related Tyrosine Kinase 4, Fc Chimera
Cat.No. : | FLT4-583H |
Product Overview : | Recombinant human soluble Vascular Endothelial Growth Factor Receptor-3 (sVEGFR-3) was fused with the Fc part of human IgG1. The recombinant mature sVEGFR-3/Fc is a disulfide-linked homodimeric protein. The sVEGFR-3/Fc monomers have a mass of approximately 130 kDa. The soluble receptor protein consists of all 7 extracellular domains (Met1-Glu774). It is produced inInsect cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FLT4-583H |
Description : | All three VEGF receptors belong to the class III subfamily of receptor tyrosine kinases (RTKs) characterised by the seven immunoglobulin-like loops in the extracellular domain. The expression of VEGFR-1 to -3 is almost exclusively restricted to hematopoietic precursor cells, vascular and lymphatic endothelial cells and to the monocyte/macrophage lineage. They play key roles in vasculogenesis, hematopoiesis, angiogenesis and lymphangiogenesis. The VEGFR-3/FLT-4 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 23 aa residue signal peptide. Mature VEGFR-3/FLT-4 is composed of a 751 aa residue extracellular domain, a 22 aa transmembrane domain and a 482 aa residue cytoplasmic domain. Both VEGF family members VEGF-C and VEGF-D have been shown to bind and activate VEGFR-3/FLT-4. |
Source : | Insect cells. |
Endotoxin Level : | < 0.1 ng per mg of soluble sVEGFR-3/Fc. |
Purity : | > 90%, by SDS-PAGE and visualised by silver stain. |
Reconstitution : | The lyophilised sVEGFR-3/Fc is soluble in water and most aqueous buffers. The lyophilized sVEGFR-3/Fc should be reconstituted in PBS or medium to a concentration not lower than 100 µg/ml. |
Specific Activity : | Measured by its ability to bind recombinant rat VEGF-C in a functional solid phase binding assay. Immobilised recombinant human sVEGFR-3/Fc at 5 µg/ml can bind recombinant rat VEGF-C in a linear range of 8-500 ng/ml. |
Stability : | Lyophilised samples are stable for greater than six months at -20℃to -70℃. Reconstituted sVEGFR-3/Fc should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles. |
Gene Name : | FLT4 fms-related tyrosine kinase 4 [ Homo sapiens ] |
Synonyms : | FLT4; fms-related tyrosine kinase 4; PCL; FLT41; LMPH1A; VEGFR3; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; vascular endothelial growth factor receptor 3; EC 2.7.10.1 |
Gene ID : | 2324 |
mRNA Refseq : | NM_002020 |
Protein Refseq : | NP_002011 |
MIM : | 136352 |
UniProt ID : | P35916 |
Chromosome Location : | 5q34-q35 |
Pathway : | Cytokine-cytokine receptor interaction; Focal adhesion; Signaling by VEGF |
Function : | ATP binding; growth factor binding; receptor activity; transferase activity; nucleotide binding; vascular endothelial growth factor receptor activity |
Products Types
◆ Recombinant Protein | ||
FLT4-2055H | Recombinant Human FLT4 Protein, Fc/His-tagged | +Inquiry |
FLT4-4413H | Recombinant Human FLT4 Protein, His (Fc)-Avi-tagged | +Inquiry |
FLT4-4378H | Active Recombinant Human FLT4 Protein, GST-tagged | +Inquiry |
Flt4-282M | Active Recombinant Mouse Flt4 protein(Met1-Glu775), His-tagged | +Inquiry |
FLT4-4379H | Recombinant Human FLT4 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
FLT4-2709HCL | Recombinant Human FLT4 cell lysate | +Inquiry |
FLT4-2016MCL | Recombinant Mouse FLT4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1594 | Flt4 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket