"3CLpro" Related Products

SARS Coronavirus Main Proteinase Complexed With Inhibitor

Cat. No.: CBCRY05
Background: The SARS-CoV main protease, which is a 33.8-kDa protease (also called the 3C-like protease), plays a pivotal role in mediating viral replication and transcription functions through extensive proteolytic processing of two replicase polyproteins, pp1a (486 kDa) and pp1ab (790 kDa).
Protein Classification: Hydrolase
Structure Weight: 69623.62
Polymer: 1
Molecule: 3C-like proteinase
Chain Length: 306 amino acids
PDB ID: 1UK4
MMDB ID: 25518
Source: E.coli
Method: X-Ray Diffraction
Resolution: 2.5Å
Ligand Chemical Component: Chloroacetone
Reference: Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-13195.
Gene Name: NEWENTRY
Synonyms: 3C-like proteinase
Gene ID: 2831005
Function: RNA binding; catalytic activity; RNA-directed RNA polymerase activity; peptidase activity; cysteine-type peptidase activity; zine ion binding; hydrolase activity; metal ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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