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Recombinant Murine Granzyme B

Cat. No.: Gzmb-942M
Product Overview: Recombinant murine Granzyme B produced inInsect cellsis a glycosylated 227 amino acid protein, comprising the mature active portion of the murine Granzyme B.
Description: Granzyme B is a cysteine protease found in the cytoplasmic granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme B is required for the induction of target cell lysis, which occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. Proteolytic cleavage of substrates by Granzyme B takes place primarily after aspartic acid residues.
Source: Insect cells.
Purity: > 98% by SDS-PAGE.
Endotoxin Level: < 0.1 ng per μg of Granzyme-B.
Stabilizer: None.
Formulation: Lyophilized.
Biological Activity: Determined by its ability to cleave a synthetic chromogentic Granzyme B substrate. The expected specific activity, when using the Ac-IEPD-pNA substrate at 25℃, is greater than 750 nM/min per μg of enzyme.
Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted Granzyme-B is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles.
Gene Name: Gzmb granzyme B [ Mus musculus ]
Synonyms: Gzmb; granzyme B; GZB; CCP1; Ctla1; Ctla-1; AI553453; CCP-1/C11; EC 3.4.21.79
Gene ID: 14939
mRNA Refseq: NM_013542
Protein Refseq: NP_038570
UniProt ID: P04187
Chromosome Location: 14 20.5 cM
Pathway: Allograft rejection; Autoimmune thyroid disease; Graft-versus-host disease; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus
Function: hydrolase activity; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity

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