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Mu-crystallin homolog

Cat.No. : CBCRY14
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  • Gene Information
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Cat. No. : CBCRY14
Background : Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Multiple alternatively spliced transcript variants have been found for this gene.
Protein Classification : Oxidoreductase
Structure Weight : 68589.65 Da
Polymer : 1
Molecule : Mu-crystallin homolog
Chain Length : 312 amino acids
PDB ID : 2I99
MMDB ID : 44495
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.6Å
Ligand Chemical Component : NAD
Reference : Cheng, Z., Sun, L., He, J., Gong, W.(2007) Crystal structure of human {micro}-crystallin complexed with NADPHProtein Sci.16: 329-335
Gene Name : CRYM
Synonyms : DFNA40; THBP; NADP-regulated thyroid-hormone binding protein; OTTHUMP00000115878; dfna40; crystallin mu
UniProt ID : Q14894
Gene ID : 1428
Chromosome Location : 16p13.11-p12.3
Function : NADP or NADPH binding; catalytic activity; thyroid hormone binding; transcription corepressor activity

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