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Recombinant Human NR1H2, LB Domain, 211-461aa, GST-tagged

Cat. No.: NR1H2-1061H
Description: Liver X Receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXRα and LXRβ. LXRα is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXRβ expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with Retinoid X Receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXRβ expressed in livers of LXRα knockout mice does not compensate for the loss of LXRα. In addition, LXRβ, but not LXRα, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXRβ may have different biological functions. Recombinant LXR is isolated from anE. colistrain that carries the coding sequence of the human LXR from amino acids 211-461 under the control of a T7 promoter.
Source: E. coli.
Application: LXR has been applied in DNA and protein-protein interactions assays.
Usage: For in vitro use only.
Form: Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM DTT and 20% glycerol.
Activity: 20 ng are sufficient for a gel-mobility shift assay and 100 ng are sufficient for a protein-protein interaction assay.
Purity: > 95% by SDS-PAGE.
Storage: Quality guaranteed for 12 months, Store at -80°C. Avoid freeze / thaw cycles.
Gene Name: NR1H2 nuclear receptor subfamily 1, group H, member 2 [ Homo sapiens ]
Synonyms: NR1H2; nuclear receptor subfamily 1, group H, member 2; NER; UNR; LXRB; LXR-b; NER-I; RIP15; LX receptor beta; liver X receptor beta; liver X receptor-beta; nuclear orphan receptor LXR-beta; oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor
Gene ID: 7376
mRNA Refseq: NM_007121
Protein Refseq: NP_009052
MIM: 600380
UniProt ID: P55055
Chromosome Location: 19q13.3-q13.3
Pathway: Gene Expression
Function: metal ion binding; protein binding; sequence-specific DNA binding; thyroid hormone receptor activity; transcription coactivator activity; zinc ion binding; steroid hormone receptor activity

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