Recombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2 NRID2-1150H

Recombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2


Home / Products / Recombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2

Recombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2

NR1D2 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat. No. : NRID2-1150H
Description : Nuclear receptors form the largest known family of transcription factors and have a crucial role in nearly all aspects of vertebrate development and adult physiology by transducing the effects of hormones into transcriptional responses. The Rev-erb family of proteins are orphan members of the receptor superfamily. Two isoforms of the Rev-erb family have been isolated from mammalian genotypes, Rev-erbA [alpha] and Rev-erbA [beta]/RVR. Major differences between the two isoforms occur within the hyper-variable A/B and D regions of the proteins. The Rev-erb family has also been demonstrated to bind as homodimers to novel HREs consisting of two tandemly arranged AGGTCA motifs, separated by 2 bp with unique 5' flanking and spacer nucleotides (RevDR-2). Reports on the transcriptional properties of the Reverb family were initially conflicting. Rev-erbA [alpha] was first reported to act as a constitutive activator of transcription through its cognate monomeric asymmetric motif. Recently, it has been demonstrated that members of the Rev-erb family are, in fact, dominant repressors of transcription. Rev-erbA [beta] is expressed in the central nervous system, skeletal and dorsal muscles, spleen and mandibular and maxillar processes. During embryogenesis RVR is expressed in the notochord and neural tube, but its function/role during differentiation and mammalian development remains obscure.
Source : Sf9 insect cells.
Usage : For in vitro use only.
Form : Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.
Activity : 1 ng is the amount sufficient for a gel mobility shift assay in a 20μl reaction and 100 ng are sufficient for a protein-protein interaction assay detected by immuno-blot system.
Purity : > 95% by SDS-PAGE.
Storage : Quality guaranteed for 12 months, Store at -80℃. Avoid freeze / thaw cycles.
Gene Name : NR1D2 nuclear receptor subfamily 1, group D, member 2 [ Homo sapiens ]
Synonyms : NR1D2; nuclear receptor subfamily 1, group D, member 2; RVR; BD73; EAR-1R; rev-erb-beta; rev-erba-alpha-related receptor; orphan nuclear hormone receptor BD73
Gene ID : 9975
mRNA Refseq : NM_001145425
Protein Refseq : NP_001138897
MIM : 602304
UniProt ID : Q14995
Chromosome Location : 3p24.1
Function : metal ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; zinc ion binding

Online Inquiry

  • Note: There will be extra charge for optional service!
  • Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy