Recombinant Human Heat Shock Protein, Alpha-crystallin-related, B6

• Cat.No.: HSPB6-1253H
• Product Overview: Recombinant Human Heat Shock Protein 20 was expressed inE.Coli.

Specification

• Cat. No.: HSPB6-1253H
• Description: Hsp20 is a mammalian small heat-shock protein family that is found most copiously in skeletal muscle and heart. The heat-shock proteins seem to act as chaperones that can protect other proteins against heat-induced denaturation and aggregation. The Hsp20 family is characterized structurally by the presence of a conserved C-terminal domain of about 100 residues and contains a beta-sandwich fold consisting of 8 strands in 2 beta-sheets in a "Greek-key" topology. Hsp20 proteins have a tendency to form dimers, through a disulphide linkage formed by an N-terminal cysteine, low heat stability and a poor chaperoning ability in comparison with other family members.
• Source: Escherichia Coli.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Formulation: HSP20 lyophilized from 20mM Tris-acetate, pH-7.6, 10mM NaCl, 0.1mM EDTA, 0.1mM PMSF and 15mMβ-mercaptoethanol.
• Stability: HSP20 although stable at 10°C for 2 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
• Immunological Activity: Immunoreactivity is confirmed by reaction with monoclonal mouse antibodies against HSP20.

Gene Information

• Gene Name: HSPB6 heat shock protein, alpha-crystallin-related, B6 [ Homo sapiens ]
• Synonyms: heat shock protein, alpha-crystallin-related, B6; Hsp20; FLJ32389; HSPB6b;HspB6;HSP20; Heat shock 20 kDa-like protein p20
• Gene ID: 126393
• mRNA Refseq: NM_144617
• Protein Refseq: NP_653218
• MIM: 610695
• UniProt ID: O14558
• Chromosome Location: 19q13.12
• Function: protein binding