Recombinant Human Alpha Hemoglobin Stabilizing Protein

• Cat.No.: AHSP-1392H
• Product Overview: Recombinant Human AHSP protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 11.8 kDa (102aa).

Specification

• Cat. No.: AHSP-1392H
• Description: AHSP(Alpha-hemoglobin stabilizing protein), also known as ERAF(Erythroid associated factor), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of α-hemoglobin during normal erythroid cell development. It specifically protects free α-hemoglobin from precipitation in live cells and in solution. This protein is downregulated in transmissible spongiform encephalopathies (TSEs). It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.
• Source: E.coli.
• Amino Acid Sequence: MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 10% glycerol.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: AHSP alpha hemoglobin stabilizing protein [ Homo sapiens ]
• Synonyms: AHSP; alpha hemoglobin stabilizing protein; EDRF; ERAF; alpha hemoglobin stabilising protein; erythroid differentiation-related factor; erythroid differentiation associated factor; erythroid associated factor; Erythroid-associated factor; Alpha-hemoglobin-stabilizing protein
• Gene ID: 51327
• mRNA Refseq: NM_016633
• Protein Refseq: NP_057717
• MIM: 605821
• UniProt ID: Q9NZD4
• Chromosome Location: 16p11.1
• Function: hemoglobin binding; unfolded protein binding