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Recombinant Human Phosphatidylethanolamine Binding Protein 1

Cat. No.: PEBP1-1400H
Product Overview: Recombinant human PEBP1 was expressed inE.coliand purified by using conventional chromatography techniques. MW =21 kDa (187aa).
Description: Phosphatidylethanolamine binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein (RKIP), is a member of the phosphatidylethanolamine-binding protein family and a serine protease inhibitor which inhibits thrombin, neuropsin. PEBP1 plays a pivotal modulatory role in several protein kinase signaling cascades. Protein kinase C (PKC) phosphorylates PEBP1, resulting in release of Raf-1 and activation of MEK and ERK. Expressed in many tissues, PEBP1 is implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, and metastasis suppression.
Source: E.coli.
Amino Acid Sequence: MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL YEQLSGK
Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol.
Purity: > 95% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PEBP1 phosphatidylethanolamine binding protein 1 [ Homo sapiens ]
Synonyms: PEBP1; phosphatidylethanolamine binding protein 1; PBP; HCNP; PEBP; RKIP; prostatic binding protein; Raf kinase inhibitory protein; hippocampal cholinergic neurostimulating peptide; HCNPpp; PEBP-1; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein; Phosphatidylethanolamine-binding protein 1
Gene ID: 5037
mRNA Refseq: NM_002567
Protein Refseq: NP_002558
MIM: 604591
UniProt ID: P30086
Chromosome Location: 12q24
Function: ATP binding; lipid binding; mitogen-activated protein kinase binding; nucleotide binding; peptidase inhibitor activity; phosphatidylethanolamine binding; receptor binding; serine-type endopeptidase inhibitor activity

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