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Recombinant Human Glycogen Phosphorylase B

Cat.No. : PYGB-366H
Product Overview : Recombinant Human Glycogen Phosphorylase produced inE.Coliis a single, non-glycosylated, polypeptide chain. The Human GPBB mature chain: 2 - 843 aa; that is a total of 842 aa having a molecular mass of 96695.96 Dalton. The theoretical pI is 6.40. The GPBB is purified by proprietary chromatographic techniques.
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Cat. No. : PYGB-366H
Description : Glycogen phosphorylase is one of the phosphorylaseenzymes (EC2.4.1.1). It breaks up glycogeninto glucosesubunits. Glycogenis left with one less glucosemolecule, and the free glucosemolecule is in the form of glucose-1-phosphate. In order to be used for metabolism, it must be converted to glucose-6-phosphateby the enzyme phosphoglucomutase. Glycogen phosphorylase can only act on linearchainsof glycogen (a 1-4 glycosidic linkage). Its work will immediately come to a halt four residues away from a 1-6 branch (which are exceedingly common in glycogen). In these situations, a debranching enzymeis necessary, which will straighten out the chain in that area. Additionally, an alpha 1-6 glucosidaseenzymeis required to break the remaining 1-6 residue that remains in the new linear chain. After all this is done, glycogen phosphorylase can continue.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered colourless liquid formualtion.
Formulation : 0.8 mg/1ml, each mg of protein contains 50% glycerol.
Applications : Immunoassays and western blot.
Purity : Greater than 85.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Storage : GPBB although stable at 10°C for 7 days, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name : PYGB phosphorylase, glycogen; brain [ Homo sapiens ]
Synonyms : PYGB; phosphorylase, glycogen; brain; MGC9213; glycogen phosphorylase B; EC 2.4.1.1; GPBB
Gene ID : 5834
mRNA Refseq : NM_002862
Protein Refseq : NP_002853
MIM : 138550
UniProt ID : P11216
Chromosome Location : 20p11.2-p11.1
Pathway : Insulin signaling pathway; Starch and sucrose metabolism
Function : glycogen phosphorylase activity; pyridoxal phosphate binding; transferase activity, transferring glycosyl groups

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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