|Cat. No. :
|Product Overview :
||Recombinant full-length human LYN A was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=81 kDa.
||LYN A is a member of the Src-family of protein kinases that participate in signaling pathways of a variety of cell surface receptors and are localized to the cytoplasmic side of the plasma membrane. LYN A is biosynthetically transported to the plasma membrane via the Golgi pool of caveolin along the secretory pathway. The trafficking of LYN A from the Golgi apparatus to the plasma membrane is inhibited by deletion of the kinase domain but not by kinase inactivation. The kinase domain of LYN A plays a role in LYN A trafficking besides catalysis of substrate phosphorylation. cDNA microarray analysis revealed that LYN A may be involved in the changes that are related to tumor pathogenesis.
||Sf9 insect cellsusing baculovirus.
||Kinase Assay, Western Blot.
|Storage And Stability :
||Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
|PDB rendering based on 1wa7. :