Recombinant Human TXK Tyrosine Kinase, GST-tagged, Active


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Recombinant Human TXK Tyrosine Kinase, GST-tagged, Active

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Cat. No. : TXK-453H
Product Overview : Recombinant human TXK (239-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag.MW = 53 kDa.
Description : TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor. TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity.. Excessive TXK protein expression is seen in patients with Behcet"s disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet's disease.
Source : Sf9 insect cells using baculovirus.
Sequence : 239-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 2dm0. :

Gene Name : TXK TXK tyrosine kinase [ Homo sapiens ]
Synonyms : TXK tyrosine kinase; RLK; TKL; BTKL; PTK4; PSCTK5; MGC22473; TXK; tyrosine kinase; PTK4 protein tyrosine kinase 4; EC
Gene ID : 7294
mRNA Refseq : NM_003328
Protein Refseq : NP_003319
MIM : 600058
UniProt ID : P42681
Chromosome Location : 4p12
Pathway : Leukocyte transendothelial migration
Function : non-membrane spanning protein tyrosine kinase activity; nucleotide binding; ATP binding; transferase activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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