"ZAK" Related Products

Recombinant Human ZAK, GST-tagged, Active

Cat. No. : ZAK-457H
Product Overview : Recombinant full-length human ZAK was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 82 kDa.
Description : ZAK is a member of the MAPKKK family of signal transduction molecules and mediates gamma radiation signaling leading to cell cycle arrest. The activity of ZAK plays a role in cell cycle checkpoint regulation as well as being involved in regulating actin organization. Expression of kinase-dead ZAK in mouse fibroblasts disrupts actin stress fibers and causes morphologic changes. ZAK can activate JNK through MKK4/MKK7 and ERK5/p38-gamma via MKK3/MKK6. Expression of ZAK increases the population of cells in the G2/M phase of the cell cycle, whereas dominant-negative ZAK attenuated the G2 arrest caused by gamma radiation.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : ZAK sterile alpha motif and leucine zipper containing kinase AZK [ Homo sapiens ]
Synonyms : sterile alpha motif and leucine zipper containing kinase AZK; ZAK; AZK; MLT; MRK; MLK7; MLTK; mlklak; MLK-related kinase; mixed lineage kinase 7; cervical cancer suppressor gene 4 protein; mixed lineage kinase-related kinase MRK-beta; MLK-like mitogen-activated protein triple kinase; mitogen-activated protein kinase kinase kinase MLT; leucine zipper- and sterile alpha motif-containing kinase; mixed lineage kinase with a leucine zipper and a sterile alpha motif; EC; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase ; Mixed lineage kinase-related kinase ; Sterile alpha motif- and leucine zipper-containing kinase AZK
Gene ID : 51776
mRNA Refseq : NM_016653
Protein Refseq : NP_057737
MIM : 609479
UniProt ID : Q9NYL2
Chromosome Location : 2q24.2
Pathway : MAPK signaling pathway; Tight junction
Function : ATP binding; MAP kinase kinase kinase activity; identical protein binding; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity

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