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Recombinant Human ZAK, GST-tagged, Active

Cat.No. : ZAK-457H
Product Overview : Recombinant full-length human ZAK was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 82 kDa.
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Cat. No. : ZAK-457H
Description : ZAK is a member of the MAPKKK family of signal transduction molecules and mediates gamma radiation signaling leading to cell cycle arrest. The activity of ZAK plays a role in cell cycle checkpoint regulation as well as being involved in regulating actin organization. Expression of kinase-dead ZAK in mouse fibroblasts disrupts actin stress fibers and causes morphologic changes. ZAK can activate JNK through MKK4/MKK7 and ERK5/p38-gamma via MKK3/MKK6. Expression of ZAK increases the population of cells in the G2/M phase of the cell cycle, whereas dominant-negative ZAK attenuated the G2 arrest caused by gamma radiation.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : ZAK sterile alpha motif and leucine zipper containing kinase AZK [ Homo sapiens ]
Synonyms : sterile alpha motif and leucine zipper containing kinase AZK; ZAK; AZK; MLT; MRK; MLK7; MLTK; mlklak; MLK-related kinase; mixed lineage kinase 7; cervical cancer suppressor gene 4 protein; mixed lineage kinase-related kinase MRK-beta; MLK-like mitogen-activated protein triple kinase; mitogen-activated protein kinase kinase kinase MLT; leucine zipper- and sterile alpha motif-containing kinase; mixed lineage kinase with a leucine zipper and a sterile alpha motif; EC 2.7.11.25; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase ; Mixed lineage kinase-related kinase ; Sterile alpha motif- and leucine zipper-containing kinase AZK
Gene ID : 51776
mRNA Refseq : NM_016653
Protein Refseq : NP_057737
MIM : 609479
UniProt ID : Q9NYL2
Chromosome Location : 2q24.2
Pathway : MAPK signaling pathway; Tight junction
Function : ATP binding; MAP kinase kinase kinase activity; identical protein binding; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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