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Recombinant Human ACADM, His-tagged

Cat.No. : ACADM-26047TH
Product Overview : Recombinant Human full length ACADM with a N terminal His tag; a single, non-glycosylated polypeptide chain; 417 amino acids with tag; predicted Mwt: 45.9 kDa.
  • Specification
  • Gene Information
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Description : This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein length : 396 amino acids
Conjugation : HIS
Molecular Weight : 45.900kDa
Source : E. coli
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : pH: 7.50Constituents:20% Glycerol, 0.32% Tris HCl
Storage : Please see Notes section
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MKANRQREPG LGFSFEFTEQ QKEFQATARK FAREEIIPVA AEYDKTGEYP VPLIRRAWEL GLMNTHIPEN CGGLGLGTFD ACLISEELAY GCTGVQTAIE GNSLGQMPII IAGNDQQKKK YLGRMTEEPL MCAYCVTEPG AGSDVAGIKT KAEKKGDEYI INGQKMWITN GGKANWYFLL ARSDPDPKAP ANKAFTGFIV EADTPGIQIG RKELNMGQRC SDTRGIVFED VKVPKENVLI GDGAGFKVAM GAFDKTRPVV AAGAVGLAQR ALDEATKYAL ERKTFGKLLV EHQAISFMLA EMAMKVELAR MSYQRAAWEV DSGRRNTYYA SIAKAFAGDI ANQLATDAVQ ILGGNGFNTE YPVEKLMRDA KIYQIYEGTS QIQRLIVARE HIDKYKN
Sequence Similarities : Belongs to the acyl-CoA dehydrogenase family.
Gene Name : ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain [ Homo sapiens ]
Official Symbol : ACADM
Synonyms : ACADM; acyl-CoA dehydrogenase, C-4 to C-12 straight chain; acyl Coenzyme A dehydrogenase, C 4 to C 12 straight chain; medium-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD1; MCAD; MCADH;
Gene ID : 34
mRNA Refseq : NM_000016
Protein Refseq : NP_000007
MIM : 607008
Uniprot ID : P11310
Chromosome Location : 1p31
Pathway : Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, organism-specific biosystem; Beta oxidation of octanoyl-CoA to hexanoyl-CoA, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Fatty Acid Beta Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem;
Function : acryloyl-CoA reductase activity; acyl-CoA dehydrogenase activity; acyl-CoA dehydrogenase activity; acyl-CoA dehydrogenase activity; acyl-CoA dehydrogenase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does the activity of this protein contribute to cellular metabolism? 11/21/2021

The activity of acyl-CoA dehydrogenase medium chain contributes to the breakdown of medium-chain fatty acids to produce energy in cells.

Are there any known inhibitors or activators of this protein? 12/24/2020

There are currently no known inhibitors or activators of acyl-CoA dehydrogenase medium chain protein.

What research is currently being conducted to further understand the function of acyl-CoA dehydrogenase medium chain protein? 02/05/2020

Research is ongoing to further understand the function and regulation of acyl-CoA dehydrogenase medium chain protein, as well as its role in metabolic disorders.

What diseases or disorders are associated with mutations in this protein? 10/27/2018

Mutations in this protein are associated with a variety of metabolic disorders, including medium-chain acyl-CoA dehydrogenase deficiency.

How is the expression of acyl-CoA dehydrogenase medium chain regulated? 09/08/2017

The expression of acyl-CoA dehydrogenase medium chain is regulated by a variety of factors, including gene expression and protein degradation pathways.

Where is acyl-CoA dehydrogenase medium chain protein located within the cell? 06/21/2017

Acyl-CoA dehydrogenase medium chain protein is located in the mitochondrial matrix.

What is the substrate specificity of this protein? 02/21/2016

Acyl-CoA dehydrogenase medium chain protein has specificity for medium-chain fatty acyl-CoA substrates.

What is the structure of this protein and how does it relate to its function? 09/27/2015

Acyl-CoA dehydrogenase medium chain protein has a flavin adenine dinucleotide (FAD)-binding domain that is essential for its function.

What is the function of acyl-CoA dehydrogenase medium chain protein? 08/25/2015

Acyl-CoA dehydrogenase medium chain protein catalyzes the first step in the 尾-oxidation of medium-chain fatty acids.

What are the physiological roles of acyl-CoA dehydrogenase medium chain? 06/25/2015

Acyl-CoA dehydrogenase medium chain plays a key role in energy metabolism and fatty acid oxidation in cells.

Customer Reviews (2)

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Reviews
04/29/2022

    Demonstrates excellent stability and consistency in long-term storage.

    05/25/2018

      Highly effective in detecting post-translational modifications of the target protein.

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