"ACADM" Related Products

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Recombinant Human ACADM, His-tagged

Cat.No.: ACADM-26047TH
Product Overview: Recombinant Human full length ACADM with a N terminal His tag; a single, non-glycosylated polypeptide chain; 417 amino acids with tag; predicted Mwt: 45.9 kDa.
Description: This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein length: 396 amino acids
Conjugation: HIS
Molecular Weight: 45.900kDa
Source: E. coli
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: pH: 7.50Constituents:20% Glycerol, 0.32% Tris HCl
Storage: Please see Notes section
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MKANRQREPG LGFSFEFTEQ QKEFQATARK FAREEIIPVA AEYDKTGEYP VPLIRRAWEL GLMNTHIPEN CGGLGLGTFD ACLISEELAY GCTGVQTAIE GNSLGQMPII IAGNDQQKKK YLGRMTEEPL MCAYCVTEPG AGSDVAGIKT KAEKKGDEYI INGQKMWITN GGKANWYFLL ARSDPDPKAP ANKAFTGFIV EADTPGIQIG RKELNMGQRC SDTRGIVFED VKVPKENVLI GDGAGFKVAM GAFDKTRPVV AAGAVGLAQR ALDEATKYAL ERKTFGKLLV EHQAISFMLA EMAMKVELAR MSYQRAAWEV DSGRRNTYYA SIAKAFAGDI ANQLATDAVQ ILGGNGFNTE YPVEKLMRDA KIYQIYEGTS QIQRLIVARE HIDKYKN
Sequence Similarities: Belongs to the acyl-CoA dehydrogenase family.
Gene Name: ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain [ Homo sapiens ]
Official Symbol: ACADM
Synonyms: ACADM; acyl-CoA dehydrogenase, C-4 to C-12 straight chain; acyl Coenzyme A dehydrogenase, C 4 to C 12 straight chain; medium-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD1; MCAD; MCADH;
Gene ID: 34
mRNA Refseq: NM_000016
Protein Refseq: NP_000007
MIM: 607008
Uniprot ID: P11310
Chromosome Location: 1p31
Pathway: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, organism-specific biosystem; Beta oxidation of octanoyl-CoA to hexanoyl-CoA, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Fatty Acid Beta Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem;
Function: acryloyl-CoA reductase activity; acyl-CoA dehydrogenase activity; acyl-CoA dehydrogenase activity; acyl-CoA dehydrogenase activity; acyl-CoA dehydrogenase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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