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Recombinant Human AGRN, His-tagged

Cat.No.: AGRN-26658TH
Product Overview: Recombinant fragment, corresponding to amino acids 1601-2045 of Human Agrin with a N terminal His tag; 52kDa.
Description: This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found.
Conjugation: HIS
Source: E. coli
Form: Lyophilised:Reconstitution with 127 μl aqua dest.
Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: APCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADF NGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLL YNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSR EPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTV LNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLG GRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASC VPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSG KATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVN TNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLD TDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHP LHLLEDAVTKPELRPCPTP
Gene Name: AGRN agrin [ Homo sapiens ]
Official Symbol: AGRN
Synonyms: AGRN; agrin; AGRIN; agrin proteoglycan;
Gene ID: 375790
mRNA Refseq: NM_198576
Protein Refseq: NP_940978
MIM: 103320
Uniprot ID: O00468
Chromosome Location: 1p36.33
Pathway: Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem;
Function: acetylcholine receptor regulator activity; laminin binding; protein binding; structural constituent of cytoskeleton;

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