||Recombinant fragment, corresponding to amino acids 1601-2045 of Human Agrin with a N terminal His tag; 52kDa.
||This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found.
||Lyophilised:Reconstitution with 127 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||APCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADF NGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLL YNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSR EPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTV LNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLG GRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASC VPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSG KATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVN TNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLD TDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHP LHLLEDAVTKPELRPCPTP