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Recombinant Human BAD

Cat.No.: BAD-26296TH
Product Overview: Recombinant full length BAD protein (Human) with N-terminal 26 kDa proprietary tag, expressed in E. coli.
Description: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
Source: E. coli
Tissue specificity: Expressed in a wide variety of tissues.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the Bcl-2 family.
Gene Name: BAD BCL2-associated agonist of cell death [ Homo sapiens ]
Official Symbol: BAD
Synonyms: BAD; BCL2-associated agonist of cell death; bcl2 antagonist of cell death; BBC2; BCL2L8;
Gene ID: 572
mRNA Refseq: NM_004322
Protein Refseq: NP_004313
MIM: 603167
Uniprot ID: Q92934
Chromosome Location: 11q13.1
Pathway: AKT phosphorylates targets in the cytosol, organism-specific biosystem; Activation of BAD and translocation to mitochondria, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem;
Function: cysteine-type endopeptidase activator activity involved in apoptotic process; lipid binding; phospholipid binding; protein binding; protein heterodimerization activity;

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