Recombinant Human BBOX1, His-tagged

• Cat.No.: BBOX1-26648TH
• Product Overview: Recombinant fragment, corresponding to amino acids 100-387 of Human BBOX1 with N terminal His tag; 288 amino acids, 34kDa.

Specification

• Description: This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitute with 92 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: ARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYK WLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFY GHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLL HCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSST FVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNN ATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMN PGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDV VMSRLRILRQRVENGN

Gene Information

• Gene Name: BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 [ Homo sapiens ]
• Official Symbol: BBOX1
• Synonyms: BBOX1; butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; BBOX; gamma-butyrobetaine dioxygenase; BBH; G BBH; gamma BBH
• Gene ID: 8424
• mRNA Refseq: NM_003986
• Protein Refseq: NP_003977
• MIM: 603312
• Uniprot ID: O75936
• Chromosome Location: 11p
• Pathway: Carnitine synthesis, organism-specific biosystem; Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem
• Function: gamma-butyrobetaine dioxygenase activity; gamma-butyrobetaine dioxygenase activity; gamma-butyrobetaine dioxygenase activity; iron ion binding; metal ion binding