Recombinant Human BCR BCR-26665TH

Recombinant Human BCR

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Recombinant Human BCR

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Cat.No. : BCR-26665TH
Product Overview : Recombinant fragment, corresponding to N terminal amino acids 1-695 of Human Bcr expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 120kDa.
Description : A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : BCR breakpoint cluster region [ Homo sapiens ]
Official Symbol : BCR
Synonyms : BCR; breakpoint cluster region; BCR1, D22S11; breakpoint cluster region protein; ALL; CML; D22S662; PHL;
Gene ID : 613
mRNA Refseq : NM_004327
Protein Refseq : NP_004318
MIM : 151410
Uniprot ID : P11274
Chromosome Location : 22q11
Pathway : Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; Pathways in cancer, organism-specific biosystem; Regulation of RAC1 activity, organism-specific biosystem; Regulation of RhoA activity, organism-specific biosystem;
Function : ATP binding; GTPase activator activity; Rac GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity;

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