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Recombinant Human BMF, T7 -tagged

Cat.No.: BMF-27487TH
Product Overview: Recombinant full length Human Bmf isoform 3 , with N terminal T7 tag, Predicted MWt 15.6 kDa.
Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Conjugation: T7
Source: E. coli
Tissue specificity: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MASMTGGQQM GRGSHMEPSQ CVEELEDDVF QPEDGEPVTQ PGSLLSADLF AQSLLDCPLS RLQLFPLTHC CGPGLRPTSQ EDKATQTLSP ASPSQGVMLP CGVTEEPQRL FYAPAEPKSC VVADPPLPAQ PCFEWRREQE RGRP
Sequence Similarities: Belongs to the Bcl-2 family.
Gene Name: BMF Bcl2 modifying factor [ Homo sapiens ]
Official Symbol: BMF
Synonyms: BMF; Bcl2 modifying factor; bcl-2-modifying factor; FLJ00065;
Gene ID: 90427
mRNA Refseq: NM_033503
Protein Refseq: NP_277038
MIM: 606266
Uniprot ID: Q96LC9
Chromosome Location: 15q14
Pathway: Activation of BH3-only proteins, organism-specific biosystem; Activation of BMF and translocation to mitochondria, organism-specific biosystem; Apoptosis, organism-specific biosystem; Intrinsic Pathway for Apoptosis, organism-specific biosystem;
Function: protein binding;

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