Recombinant Human BMF, T7 -tagged

• Cat.No.: BMF-27487TH
• Product Overview: Recombinant full length Human Bmf isoform 3 , with N terminal T7 tag, Predicted MWt 15.6 kDa.

Specification

• Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Conjugation: T7
• Source: E. coli
• Tissue specificity: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MASMTGGQQM GRGSHMEPSQ CVEELEDDVF QPEDGEPVTQ PGSLLSADLF AQSLLDCPLS RLQLFPLTHC CGPGLRPTSQ EDKATQTLSP ASPSQGVMLP CGVTEEPQRL FYAPAEPKSC VVADPPLPAQ PCFEWRREQE RGRP
• Sequence Similarities: Belongs to the Bcl-2 family.

Gene Information

• Gene Name: BMF Bcl2 modifying factor [ Homo sapiens ]
• Official Symbol: BMF
• Synonyms: BMF; Bcl2 modifying factor; bcl-2-modifying factor; FLJ00065
• Gene ID: 90427
• mRNA Refseq: NM_033503
• Protein Refseq: NP_277038
• MIM: 606266
• Uniprot ID: Q96LC9
• Chromosome Location: 15q14
• Pathway: Activation of BH3-only proteins, organism-specific biosystem; Activation of BMF and translocation to mitochondria, organism-specific biosystem; Apoptosis, organism-specific biosystem; Intrinsic Pathway for Apoptosis, organism-specific biosystem
• Function: protein binding