Native Human Calpain-1


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Native Human Calpain-1

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Cat.No. : CAPN1-27397TH
Product Overview : Native Human Calpain-1 was purified from Human Erythrocyte.
Description : The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
Source : Human Erythrocyte
Species : Human
Form : Frozen in 20 mM imidazole, 5mM β-mercaptoethanol, 1 mM EDTA, 1mM EGTA, 30% glycerol, pH 6.8
Bio-activity : Greater than or equal to 1,000 units per mg protein. One unit is de ned as the amount of enzyme that hydrolyzes one ρmole Suc-LLVY-AMC per minute at 25o C.
Molecular Mass : 110,000 Daltons
Purity : Greater than or equal to 95% by SDS-PAGE.
Storage : -70°C or lower
Gene Name : CAPN1 calpain 1, (mu/I) large subunit [ Homo sapiens (human) ]
Official Symbol : CAPN1
Synonyms : CAPN1; calpain 1, (mu/I) large subunit; calpain-1 catalytic subunit; CANP; CANPL1; muCANP; muCL; CANP 1; calpain mu-type; micromolar-calpain; calpain-1 large subunit; calpain, large polypeptide L1; calcium-activated neutral proteinase 1; cell proliferation-inducing protein 30; cell proliferation-inducing gene 30 protein
Gene ID : 823
mRNA Refseq : NM_001198868
Protein Refseq : NP_001185797
MIM : 114220
UniProt ID : P07384
Chromosome Location : 11q13
Pathway : Alzheimers disease; Apoptosis; Focal Adhesion
Function : calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; protein binding

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