"NCK1" Related Products

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Recombinant Human NCK Adaptor Protein 1, His-tagged

Cat. No.: NCK1-1473H
Product Overview: Recombinant full-length human NCK was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW = 48 kDa.
Description: NCK (or non-catalytic region of tyrosine kinase adaptor protein 1 is an adaptor protein that is located in the cytoplasm and involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. NCK is a signaling and transforming protein that contains Src homology 2 and 3 (SH2 and SH3) domains. NCK functions by coupling tyrosine phosphorylation via SH2 domains to downstream effectors through SH3 domains. Furthermore, NCK couples tyrosine phosphorylation guidance signals to cytoskeletal events required for the ipsilateral projections of spinal cord neurons and for normal limb movement.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Western Blot.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: NCK1 NCK adaptor protein 1 [ Homo sapiens ]
Synonyms: NCK1; NCK adaptor protein 1; NCK; MGC12668; NCKalpha; NCK tyrosine kinase; melanoma NCK protein; SH2/SH3 adaptor protein NCK-alpha; non-catalytic region of tyrosine kinase; Nck-1; Cytoplasmic protein NCK1
Gene ID: 4690
mRNA Refseq: NM_006153
Protein Refseq: NP_006144
MIM: 600508
UniProt ID: P16333
Chromosome Location: 3q21
Pathway: Axon guidance; ErbB signaling pathway; Pathogenic Escherichia coli infection; T cell receptor signaling pathway
Function: cytoskeletal adaptor activity; protein domain specific binding; receptor binding; receptor signaling complex scaffold activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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