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Recombinant Human CCNE1

Cat.No.: CCNE1-27521TH
Product Overview: Recombinant full length Human Cyclin E1 (amino acids 1-410) with N-terminal proprietary tag, 73kDa inclusive of tag.
Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
Protein length: 410 amino acids
Molecular Weight: 73.000kDa inclusive of tags
Source: Baculovirus infected sf9 cells
Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Form: Liquid
Purity: by SDS-PAGE
Storage buffer: pH: 7.50Constituents:25% Glycerol, 0.79% Tris HCl, 0.88% Sodium chloride, 0.31% Glutathione, 0.003% EDTA, 0.003% DTT, 0.002% PMSF
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the cyclin family. Cyclin E subfamily.
Gene Name: CCNE1 cyclin E1 [ Homo sapiens ]
Official Symbol: CCNE1
Synonyms: CCNE1; cyclin E1; CCNE; G1/S-specific cyclin-E1; cyclin Es; cyclin Et;
Gene ID: 898
mRNA Refseq: NM_001238
Protein Refseq: NP_001229
MIM: 123837
Uniprot ID: P24864
Chromosome Location: 19q12
Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem;
Function: androgen receptor binding; cyclin-dependent protein kinase regulator activity; kinase activity; protein binding; protein kinase binding;

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