"TWSG1" Related Products


Recombinant Human Twisted Gastrulation Homolog 1 (Drosophila)

Cat. No.: TWSG1-1506H
Product Overview: Recombinant human TSG is a 199 amino acid protein containing the BMP/TGFβ binding portion of the full length TSG protein expressed inE. colicells. MW=22.2 kDa.
Description: Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex.
Source: E. coli.
Quantity: 50 μg.
Purity: Greater than 98% (determined by SDS-PAGE and HPLC analysis).
Endotoxin Level: < 0.1 ng per μg of rHu TSG (1EU/μg).
Biological Activity: Determined by its ability to neutralize BMP-6 induced alkaline phosphatase production by chondrogenic cells. The expected ED50 for this effect is < 2.0 μg/ml of TSG.
Formulation: Lyophilized from a sterile-filtered solution with no additives.
Reconstitution: Please Note: Always centrifuge product before opening vial. The lyophilized protein should be reconstituted with distilled, sterile water to a concentration of 0.1-1.0 mg/ml. For further dilution, carrier protein (0.1% BSA or HSA) should be added to avoid loss of bioactivity.
Storage And Stability: The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted protein should be used immediately or stored long-term in undiluted working aliquots at -20°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.
Gene Name: TWSG1 twisted gastrulation homolog 1 (Drosophila) [ Homo sapiens ]
Synonyms: TWSG1; twisted gastrulation homolog 1 (Drosophila); TSG; Twisted gastrulation protein homolog 1; PSEC0250
Gene ID: 57045
mRNA Refseq: NM_020648
Protein Refseq: NP_065699
UniProt ID: Q9GZX9
Chromosome Location: 18p11.3
MIM: 605049
Function: protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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