Recombinant Human CSTB, His-tagged CSTB-31464TH

Recombinant Human CSTB, His-tagged

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Recombinant Human CSTB, His-tagged

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Cat.No. : CSTB-31464TH
Product Overview : Recombinant full length human Stefin B, fused to His tag; 118 amino acids, 13 kDa.
Description : The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Conjugation : HIS
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50mM Sodium chloride, 20mM Tris, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF
Sequence Similarities : Belongs to the cystatin family.
Gene Name : CSTB cystatin B (stefin B) [ Homo sapiens ]
Official Symbol : CSTB
Synonyms : CSTB; cystatin B (stefin B); EPM1, STFB; cystatin-B; CST6; PME;
Gene ID : 1476
mRNA Refseq : NM_000100
Protein Refseq : NP_000091
MIM : 601145
Uniprot ID : P04080
Chromosome Location : 21q22.3
Function : cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; protease binding;

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