Recombinant Human CTCF CTCF-26436TH

Recombinant Human CTCF

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Recombinant Human CTCF

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Cat.No. : CTCF-26436TH
Product Overview : Recombinant fragment corresponding to amino acids 1-100 of Human CTCF protein with a proprietary tag; predicted mwt: 36.63 kDa.
Description : This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa
Source : Wheat germ
Tissue specificity : Ubiquitous. Absent in primary spermatocytes.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MEGDAVEAIVEESET FIKGKERKTYQRRRE GGQEEDACHLPQNQT DGGEVVQDVNSSVQM VMMEQLDPTLLQMKT EVMEGTVAPEAEAAV DDTQIITLQV
Sequence Similarities : Belongs to the CTCF zinc-finger protein family.Contains 11 C2H2-type zinc fingers.
Gene Name : CTCF CCCTC-binding factor (zinc finger protein) [ Homo sapiens ]
Official Symbol : CTCF
Synonyms : CTCF; CCCTC-binding factor (zinc finger protein); transcriptional repressor CTCF; 11 zinc finger transcriptional repressor;
Gene ID : 10664
mRNA Refseq : NM_001191022
Protein Refseq : NP_001177951
MIM : 604167
Uniprot ID : P49711
Chromosome Location : 16q21-q22.3
Pathway : SIDS Susceptibility Pathways, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem;
Function : chromatin insulator sequence binding; metal ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity;

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