"CTDSP1" Related Products

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Recombinant Human CTDSP1, His-tagged

Cat.No.: CTDSP1-28022TH
Product Overview: Recombinant full length Human CTDSP1 (amino acids 1-260) with an N terminal His tag; 280 amino acids with a predicted MWt 31.2kDa including tag.
Description: This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein length: 260 amino acids
Conjugation: HIS
Molecular Weight: 31.200kDa inclusive of tags
Source: E. coli
Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, pH 8
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MDSSAVITQISKEEARGPLR GKGDQKSAAS QKPRSRGILH SLFCCVCRDDGEALPAHSGA PLLVEENGAI PKTPVQYLLP EAKAQDSDKICVVIDLDETL VHSSFKPVNN ADFIIPVEID GVVHQVYVLKRPHVDEFLQR MGELFECVLF TASLAKYADP VADLLDKWGAFRARLFRESC VFHRGNYVKD LSRLGRDLRR VLILDNSPASYVFHPDNAVP VASWFDNMSD TELHDLLPFF EQLSRVDDVYSVLRQPRPGS
Sequence Similarities: Contains 1 FCP1 homology domain.
Gene Name: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 [ Homo sapiens ]
Official Symbol: CTDSP1
Synonyms: CTDSP1; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; NLIIF; nuclear LIM interactor interacting factor; SCP1; small CTD phosphatase 1;
Gene ID: 58190
mRNA Refseq: NM_001206878
Protein Refseq: NP_001193807
MIM: 605323
Uniprot ID: Q9GZU7
Chromosome Location: 2q35
Pathway: BMP receptor signaling, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem;
Function: CTD phosphatase activity; hydrolase activity; metal ion binding; phosphoprotein phosphatase activity; protein binding;

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