Recombinant Human CYP1A2

• Cat.No.: CYP1A2-27559TH
• Product Overview: Recombinant fragment of Human Cytochrome P450 1A2 with N terminal proprietary tag, 36.63kDa.

Specification

• Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3 untranslated region.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Liver.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: ESSDEMLSLVKNTHEFVETASSGNP LDFFPILRYLPNPALQRFKAFNQRF LWFLQKTVQEHYQDFDKNSVRDITG ALFKHSKKGPRASGNLIPQEKIVNL
• Sequence Similarities: Belongs to the cytochrome P450 family.

Gene Information

• Gene Name: CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 [ Homo sapiens ]
• Official Symbol: CYP1A2
• Synonyms: CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 2; cytochrome P450 1A2; CP12; P3 450
• Gene ID: 1544
• mRNA Refseq: NM_000761
• Protein Refseq: NP_000752
• Uniprot ID: P05177
• Chromosome Location: 15q24.1
• Pathway: Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2, organism-specific biosystem; Biological oxidations, organism-specific biosystem; Caffeine metabolism, organism-specific biosystem; Caffeine metabolism, conserved biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem
• Function: aromatase activity; caffeine oxidase activity; demethylase activity; electron carrier activity; enzyme binding