"CYP2B6" Related Products

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Recombinant Human CYP2B6

Cat.No.: CYP2B6-28193TH
Product Overview: Recombinant full length Human Cytochrome P450 2B6 with an N terminal proprietary tag; Predicted MWt 80.08 kDa.
Description: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Protein length: 491 amino acids
Molecular Weight: 80.080kDa inclusive of tags
Source: Wheat germ
Tissue specificity: Expressed in liver, lung and heart right ventricle.
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLL GNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCG VEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKS KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLN LFYQTFSLISSVFGQLFELFSGFLTYFPGAHRQVYKNLQE INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEEEKSNAH SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHV AERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEG IARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI PPTYQIRFLPR
Sequence Similarities: Belongs to the cytochrome P450 family.
Gene Name: CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 [ Homo sapiens ]
Official Symbol: CYP2B6
Synonyms: CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6; CYP2B, cytochrome P450, family 2, subfamily B , cytochrome P450, subfamily IIB (phenobarbital inducible) , cytochrome P450, subfamily IIB (phenobarbital inducible), polypeptide 6; cytochrom
Gene ID: 1555
mRNA Refseq: NM_000767
Protein Refseq: NP_000758
MIM: 123930
Uniprot ID: P20813
Chromosome Location: 19q13.2
Pathway: Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Biological oxidations, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Drug metabolism - cytochrome P450, organism-specific biosystem;
Function: aromatase activity; electron carrier activity; heme binding; metal ion binding; monooxygenase activity;

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