Recombinant Human E2F3
Cat.No. : | E2F3-27375TH |
Product Overview : | Recombinant full length Human E2F3 with N terminal proprietary tag, 40.74kDa. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Two transcript variants encoding different isoforms have been found for this gene. |
Protein length : | 133 amino acids |
Molecular Weight : | 40.740kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MQSGGGVKTDDTSTLNSLCGYAWVYVWEEKQRCRLSSFFS SSASIPGLLPSHTLDLVQNVGVVLDEALGWGRERELCVKC LLEMHCGVFSCMGNHLCQAFPHFPYLSHLVSCLCFQLCVI LFASCTKLIFSKV |
Sequence Similarities : | Belongs to the E2F/DP family. |
Gene Name : | E2F3 E2F transcription factor 3 [ Homo sapiens ] |
Official Symbol : | E2F3 |
Synonyms : | E2F3; E2F transcription factor 3; transcription factor E2F3; |
Gene ID : | 1871 |
mRNA Refseq : | NM_001243076 |
Protein Refseq : | NP_001230005 |
MIM : | 600427 |
Uniprot ID : | O00716 |
Chromosome Location : | 6p22 |
Pathway : | Assembly of the pre-replicative complex, organism-specific biosystem; Association of licensing factors with the pre-replicative complex, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; CDC6 association with the ORC:origin complex, organism-specific biosystem; |
Function : | DNA binding; core promoter binding; cyclin-dependent protein kinase activity; protein binding; sequence-specific DNA binding transcription factor activity; |
Products Types
◆ Recombinant Protein | ||
E2F3-3006H | Recombinant Human E2F3 Protein, GST-tagged | +Inquiry |
E2F3-2596M | Recombinant Mouse E2F3 Protein, His (Fc)-Avi-tagged | +Inquiry |
E2F3-4932M | Recombinant Mouse E2F3 Protein | +Inquiry |
E2F3-12247H | Recombinant Human E2F3, His-tagged | +Inquiry |
E2F3-5118Z | Recombinant Zebrafish E2F3 | +Inquiry |
◆ Lysates | ||
E2F3-6742HCL | Recombinant Human E2F3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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