Native Human F9
Cat.No. : | F9-26523TH |
Product Overview : | Full length native Human Factor IXa purified from Human plasma, with the active site labeled by incubation with Fluorescein-Phe-Phe-Arg-CMK, MWt 45kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 0.1M Sodium chloride, 0.1M HEPES, 1mM EDTA, pH 7.4 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Gene Name : | F9 coagulation factor IX [ Homo sapiens ] |
Official Symbol : | F9 |
Synonyms : | F9; coagulation factor IX; Christmas disease; Factor IX; FIX; hemophilia B; plasma thromboplastic component; |
Gene ID : | 2158 |
mRNA Refseq : | NM_000133 |
Protein Refseq : | NP_000124 |
Uniprot ID : | P00740 |
Chromosome Location : | Xq26.3-q27.1 |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Extrinsic Pathway, organism-specific biosystem; |
Function : | calcium ion binding; peptidase activity; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
F9-915R | Recombinant Rabbit F9 Protein, His-tagged | +Inquiry |
F9-2502H | Recombinant Human F9 protein(51-120 aa), C-His-tagged | +Inquiry |
F9-3626H | Recombinant Human F9 Protein, GST-tagged | +Inquiry |
F9-914R | Recombinant Rabbit F9 Protein, His-tagged | +Inquiry |
F9-013H | Active Recombinant Human F9 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
F9-671H | Native Human Coagulation Factor IX | +Inquiry |
F9-5405M | Native Mouse Coagulation Factor IX | +Inquiry |
F9-301R | Native Rat Factor IXa | +Inquiry |
◆ Lysates | ||
F9-1849HCL | Recombinant Human F9 cell lysate | +Inquiry |
F9-1768MCL | Recombinant Mouse F9 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
- Reviews
Q&As (6)
Ask a questionThe F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.
Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.
F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.
Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.
The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).
F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.
Customer Reviews (3)
Write a reviewThe short half-life makes this product very safe.
This protein has a wide range of applications and can be used in a variety of experiments.
The method of use is simple, which reduces the experimental time and improves the efficiency.
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