||Recombinant fragment, corresponding to amino acids 49-224 of Human FKBP25 with an N-terminal His tag; Predicted MWt 21 kDa.
||The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
||Lyophilised:Reconstitute with 99 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||NVAKTANKDHLVTAYNHLFETKRFKGTESISKVSEQVKNV KLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPK KGDVVHCWYTGTLQDGTVFDTNIQTSAKKKKNAKPLSF KVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKG QPDAKIPPNAKLTFEVELVDID