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Recombinant Human HBA2

Cat.No. : HBA2-29306TH
Product Overview : Recombinant full length Human Hemoglobin subunit alpha expressed in Saccharomyces cerevisiae; amino acids 1-142 , MWt 15.2kDa. Protein is tagged with 26 kDa proprietary tag.
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  • Gene Information
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Description : The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5 untranslated regions and the introns, but they differ significantly over the 3 untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids : MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTT KTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMP NALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA EFTPAVHASLDKFLASVSTVLTSKYR
Gene Name : HBA2 hemoglobin, alpha 2 [ Homo sapiens ]
Official Symbol : HBA2
Synonyms : HBA2; hemoglobin, alpha 2; hemoglobin subunit alpha;
Gene ID : 3040
mRNA Refseq : NM_000517
Protein Refseq : NP_000508
MIM : 141850
Uniprot ID : P69905
Chromosome Location : 16p13.3
Pathway : African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Malaria, organism-specific biosystem; Malaria, conserved biosystem; Selenium Pathway, organism-specific biosystem;
Function : contributes_to haptoglobin binding; heme binding; metal ion binding; oxygen binding; oxygen transporter activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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