||Vascular endothelial growth factor receptor 3 (VEGF R3) is one of the five receptor tyrosine kinases whose expression is almost exclusively restricted to endothelial cells of the lymphatic system. VEGF R3 is a specific marker for lymphatic vessels. It has also been detected on some high endothelial venules, in embryonic prelymphatic blood vessels, in some tumor blood vessels, and in certain hematopoietic and leukemia cells. The predominant role of VEGF-R3 is its involvement in the development of the lymphatic vessel system.
|State Of Matter:
||>95% by SDS Page and analyzed by silver stain.
||<0.1 ng per 1 µg as determined by the LAL method.
||The predicted molecular weight of Recombinant Human VEGF R3 is Mr 112 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 160 kDa.
||The biological activity of Human VEGF R3 was determined by its binding ability in a functional ELISA. Immobilized VEGFR3/Fc Chimera at 5 μg/ml (100 μl/well) can bind rhVEGFD at a linear range of 4-500 ng/ml.
|Storage And Stability:
||This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.