Recombinant Human Fms-Related Tyrosine Kinase 4

• Cat.No.: FLT4-1698H

Specification

• Cat. No.: FLT4-1698H
• Description: Vascular endothelial growth factor receptor 3 (VEGF R3) is one of the five receptor tyrosine kinases whose expression is almost exclusively restricted to endothelial cells of the lymphatic system. VEGF R3 is a specific marker for lymphatic vessels. It has also been detected on some high endothelial venules, in embryonic prelymphatic blood vessels, in some tumor blood vessels, and in certain hematopoietic and leukemia cells. The predominant role of VEGF-R3 is its involvement in the development of the lymphatic vessel system.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human VEGF R3 is Mr 112 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 160 kDa.
• Biological Activity: The biological activity of Human VEGF R3 was determined by its binding ability in a functional ELISA. Immobilized VEGFR3/Fc Chimera at 5 μg/ml (100 μl/well) can bind rhVEGFD at a linear range of 4-500 ng/ml.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: FLT4 fms-related tyrosine kinase 4 [ Homo sapiens ]
• Synonyms: FLT4; fms-related tyrosine kinase 4; PCL; FLT41; LMPH1A; VEGFR3; FLT4; VEGFR-3; fms-related tyrosine kinase 4; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; vascular endothelial growth factor receptor 3; Tyrosine-protein kinase receptor FLT4; 3` partial; EC 2.7.10.1
• Gene ID: 2324
• mRNA Refseq: NM_002020
• Protein Refseq: NP_002011
• MIM: 136352
• UniProt ID: P35916
• Chromosome Location: 5q35.3
• Function: ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity